ParkinsonV1, Main, Exploration, bibRecord, 002935

Aminergic systems in Alzheimer's disease and Parkinson's disease

Identifieur interne : 002935 ( Main/Exploration ); précédent : 002934; suivant : 002936

Aminergic systems in Alzheimer's disease and Parkinson's disease

Auteurs : Robert J. D'Amato [États-Unis] ; Richard M. Zweig [États-Unis] ; Peter J. Whitehouse [États-Unis] ; Gary L. Wenk [États-Unis] ; Harvey S. Singer [États-Unis] ; Richard Mayeux [États-Unis] ; Donald L. Price [États-Unis] ; Snyder [États-Unis]

Source :

Annals of Neurology [ 0364-5134 ] ; 1987-08.

RBID : ISTEX:06BE8FFF72F0E18D7947105D03250ED533D73E0B

Abstract

Biochemical markers for serotoninegic and catecholaminergic neurons in frontal and temporal poles were examined post mortem in brains of patients with Alzheimer's disease, Parkinson's disease, and the two combined. Binding of [3H]citalopram to serotoninergic uptake sites and levels of serotonin were Decemberreased by 40 to 50% in brains of persons in each disease category. In contrast, significant reductions of catecholaminergic markers were not detected. In all three disease groups, the choline acetyltransferase activity was reduced by 50 to 60%. Binding sites for adenosine (A1), muscarinic cholinergic, phencyclidine, β‐adrenergic, and calcium antagonist receptors were unchanged. We conclude that substantial damage to serotoninergic neurons occurs in persons with Parkinson's and Alzheimer's diseases.

Url:

https://api.istex.fr/document/06BE8FFF72F0E18D7947105D03250ED533D73E0B/fulltext/pdf

DOI: 10.1002/ana.410220207

Affiliations:

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Le document en format XML

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<wicri:cityArea>Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea>
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<front><div type="abstract" xml:lang="en">Biochemical markers for serotoninegic and catecholaminergic neurons in frontal and temporal poles were examined post mortem in brains of patients with Alzheimer's disease, Parkinson's disease, and the two combined. Binding of [3H]citalopram to serotoninergic uptake sites and levels of serotonin were Decemberreased by 40 to 50% in brains of persons in each disease category. In contrast, significant reductions of catecholaminergic markers were not detected. In all three disease groups, the choline acetyltransferase activity was reduced by 50 to 60%. Binding sites for adenosine (A1), muscarinic cholinergic, phencyclidine, β‐adrenergic, and calcium antagonist receptors were unchanged. We conclude that substantial damage to serotoninergic neurons occurs in persons with Parkinson's and Alzheimer's diseases.</div>
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Aminergic systems in Alzheimer's disease and Parkinson's disease

Aminergic systems in Alzheimer's disease and Parkinson's disease

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

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